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Abstract

The present work describes the use of sildenafil citrate (Pfizer) to treat pulmonary arterial hypertension (PAH) by inhibiting phosphodiesterase type 5 (PDE5) and increasing the blood flow to the pulmonary capillaries. The drug was also shown to improve exercise tolerance in patients with PAH.

Methods

The study population comprised a group of 18 patients who were admitted to our hospital between January 2003 and December 2008 with PAH. They were evaluated for PAH at admission, after 6-month treatment with Pfizer’s sildenafil citrate (Pfizer) or placebo, as determined by an experienced pulmonologist. Pulmonary arterial hypertension (PAH) was defined as a clinical event that occurred within the previous 6 months. PAH was classified as either fatal or non-fatal in both the sildenafil citrate and placebo groups. Pulmonary artery pressure (PAP) was measured by the Doppler technique with an automated system at a standardized, 10-minute interval. The mean PAP was recorded at the time of each patient’s hospitalization and the mean pulmonary arterial pressure (PAP) was also recorded at the time of the patient’s hospitalization.

Results

A total of 13 patients (17 in Pfizer’s sildenafil citrate group and 10 in placebo group) were included in the study. Of the 13 patients, 9 (87%) were males and 9 (87%) were females. Mean age at admission was 53.2 years (SD 14.8) in the sildenafil group and 55.6 years (SD 15.1) in the placebo group. The mean pulmonary artery pressure (PAP) at the time of admission was 2.7 mm Hg (SD 1.4) in the sildenafil group and 4.8 mm Hg (SD 1.5) in the placebo group. There was no significant difference in PAP between the sildenafil and placebo groups at the time of admission. There was a significant difference in PAP between the sildenafil and placebo groups at the time of admission in both groups (P < 0.001). There was no significant difference in PAP between the sildenafil and placebo groups at the time of admission in both groups (P = 0.076).

In terms of clinical efficacy, there were no differences in PAP between the sildenafil and placebo groups. The mean pulmonary arterial pressure (PAP) at the time of admission was 3.2 mm Hg (SD 2.2) in the sildenafil group and 4.6 mm Hg (SD 2.7) in the placebo group.

Conclusion

Our study suggests that sildenafil citrate (Pfizer) is a safe and effective treatment for pulmonary arterial hypertension in patients who had PAH.

References

  1. K. J. S. S., J. M. and A. (2007) “The use of sildenafil citrate (Pfizer) in the treatment of pulmonary arterial hypertension in the elderly: a double-blind randomized, single- placebo-controlled study.”
  2. E. R. C. and E. B. P. (2004) “Phosphodiesterase type 5 inhibitors, in the treatment of pulmonary arterial hypertension.”
  3. (2001) “Phosphodiesterase type 5 inhibitors, pulmonary arterial hypertension.”
  4. M., M. and M. A. (2005) “Phosphodiesterase type 5 inhibitors, in the treatment of pulmonary arterial hypertension.”
  5. (2009) “Phosphodiesterase type 5 inhibitors, pulmonary arterial hypertension.”
  6. C., S. (2003) “Phosphodiesterase type 5 inhibitors, pulmonary arterial hypertension.”

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